Detection of the tumor-associated glycoprotein antigen (TAG-72) in premalignant lesions of the colon.
Publication/Presentation Date
12-20-1989
Abstract
We used monoclonal antibody B72.3 to study the expression of the colorectal carcinoma-associated antigen TAG-72 in premalignant colonic lesions with the immunoperoxidase technique. This antigen, which is rarely detectable in the normal colonic epithelium, was expressed in 13 of 19 adenomas with moderate to severe dysplasia and nine of nine cases of inflammatory bowel disease. The antibody reacted with the normal-appearing mucosa adjacent to a carcinoma in 10 of 12 cases, although only eight of the tumors expressed the antigen. The expression of the TAG-72 antigen in the colonic epithelium may be an early marker of malignant transformation.
Volume
81
Issue
24
First Page
1913
Last Page
1917
ISSN
0027-8874
Published In/Presented At
Wolf, B. C., D'Emilia, J. C., Salem, R. R., DeCoste, D., Sears, H. F., Gottlieb, L. S., & Steele, G. D., Jr (1989). Detection of the tumor-associated glycoprotein antigen (TAG-72) in premalignant lesions of the colon. Journal of the National Cancer Institute, 81(24), 1913–1917. https://doi.org/10.1093/jnci/81.24.1913
Disciplines
Medicine and Health Sciences
PubMedID
2593169
Department(s)
Department of Surgery
Document Type
Article