Adriamycin-vitamin E combination therapy for treatment of prostate adenocarcinoma in the Nb rat model.
Publication/Presentation Date
8-1-1988
Abstract
Adriamycin used in combination with vitamin E (Tocopherol) was evaluated in the treatment of Nb rat prostate adenocarcinoma. Vitamin E has been shown to enhance the growth-inhibitory effects of adriamycin on human prostatic carcinoma cells in vitro. The adriamycin-vitamin E treatment groups had the lowest average final tumor volume, but the mortality rate was 57% (17/30). These results suggest that vitamin E may play a role in enhancing the cytotoxic effects of adriamycin, but may not have any protective effect on normal cells as previously suggested through in vitro methods.
Volume
38
Issue
4
First Page
283
Last Page
284
ISSN
0022-4790
Published In/Presented At
Nesbitt, J. A., Smith, J., McDowell, G., & Drago, J. R. (1988). Adriamycin-vitamin E combination therapy for treatment of prostate adenocarcinoma in the Nb rat model. Journal of surgical oncology, 38(4), 283–284. https://doi.org/10.1002/jso.2930380416
Disciplines
Medicine and Health Sciences
PubMedID
3411971
Department(s)
Department of Surgery
Document Type
Article