Adriamycin-vitamin E combination therapy for treatment of prostate adenocarcinoma in the Nb rat model.

Publication/Presentation Date

8-1-1988

Abstract

Adriamycin used in combination with vitamin E (Tocopherol) was evaluated in the treatment of Nb rat prostate adenocarcinoma. Vitamin E has been shown to enhance the growth-inhibitory effects of adriamycin on human prostatic carcinoma cells in vitro. The adriamycin-vitamin E treatment groups had the lowest average final tumor volume, but the mortality rate was 57% (17/30). These results suggest that vitamin E may play a role in enhancing the cytotoxic effects of adriamycin, but may not have any protective effect on normal cells as previously suggested through in vitro methods.

Volume

38

Issue

4

First Page

283

Last Page

284

ISSN

0022-4790

Disciplines

Medicine and Health Sciences

PubMedID

3411971

Department(s)

Department of Surgery

Document Type

Article

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