Mitral Annular Disjunction in Heritable Thoracic Aortic Disease: Insights From the Montalcino Aortic Consortium.
Publication/Presentation Date
10-18-2024
Abstract
BACKGROUND: Mitral annular disjunction (MAD), posterior displacement of the mitral valve leaflet hinge point, predisposes to arrhythmias or sudden cardiac death. We evaluated the burden of MAD, mitral valve prolapse (MVP), and mitral regurgitation (MR) by heritable thoracic aortic disease gene in a cross-sectional analysis of 2014-2023 data in the Montalcino Aortic Consortium registry.
METHODS AND RESULTS: MAD was determined by direct measurement of echocardiographic images. MR and MVP were defined according to current clinical guidelines. Associations were evaluated using χ
CONCLUSIONS: Pathological mitral valve phenotypes are more prevalent in individuals with PV in transforming growth factor-β pathway genes, particularly
First Page
036274
Last Page
036274
ISSN
2047-9980
Published In/Presented At
Asokan, K. L., Landes, J. R., Renders, W., Muiño Mosquera, L., De Backer, J., Jantzen, D. W., Yetman, A. T., Teixido-Tura, G., Evangelista, A., Jeremy, R., Jones, E. G., Morris, S., Doan, T., Ouzonian, M., Braverman, A., Jondeau, G., Milleron, O., Milewicz, D. M., Prakash, S. K., & Montalcino Aortic Consortium * (2024). Mitral Annular Disjunction in Heritable Thoracic Aortic Disease: Insights From the Montalcino Aortic Consortium. Journal of the American Heart Association, e036274. Advance online publication. https://doi.org/10.1161/JAHA.124.036274
Disciplines
Medicine and Health Sciences
PubMedID
39424426
Department(s)
Department of Surgery
Document Type
Article