Graph theoretical measures of fast ripples support the epileptic network hypothesis.
Publication/Presentation Date
1-1-2022
Abstract
The epileptic network hypothesis and epileptogenic zone hypothesis are two theories of ictogenesis. The network hypothesis posits that coordinated activity among interconnected nodes produces seizures. The epileptogenic zone hypothesis posits that distinct regions are necessary and sufficient for seizure generation. High-frequency oscillations, and particularly fast ripples, are thought to be biomarkers of the epileptogenic zone. We sought to test these theories by comparing high-frequency oscillation rates and networks in surgical responders and non-responders, with no appreciable change in seizure frequency or severity, within a retrospective cohort of 48 patients implanted with stereo-EEG electrodes. We recorded inter-ictal activity during non-rapid eye movement sleep and semi-automatically detected and quantified high-frequency oscillations. Each electrode contact was localized in normalized coordinates. We found that the accuracy of seizure onset zone electrode contact classification using high-frequency oscillation rates was not significantly different in surgical responders and non-responders, suggesting that in non-responders the epileptogenic zone partially encompassed the seizure onset zone(s) (
Volume
4
Issue
3
First Page
101
Last Page
101
ISSN
2632-1297
Published In/Presented At
Weiss, S. A., Pastore, T., Orosz, I., Rubinstein, D., Gorniak, R., Waldman, Z., Fried, I., Wu, C., Sharan, A., Slezak, D., Worrell, G., Engel, J., Jr, Sperling, M. R., & Staba, R. J. (2022). Graph theoretical measures of fast ripples support the epileptic network hypothesis. Brain communications, 4(3), fcac101. https://doi.org/10.1093/braincomms/fcac101
Disciplines
Medicine and Health Sciences
PubMedID
35620169
Department(s)
Department of Surgery
Document Type
Article
