Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy.
Publication/Presentation Date
12-1-2022
Abstract
Epileptiform spikes are used to localize epileptogenic brain tissue. The mechanisms that spontaneously trigger epileptiform discharges are not yet elucidated. Pathological fast ripple (FR, 200-600 Hz) are biomarkers of epileptogenic brain, and we postulated that FR network interactions are involved in generating epileptiform spikes. Using macroelectrode stereo intracranial EEG (iEEG) recordings from a cohort of 46 patients we found that, in the seizure onset zone (SOZ), propagating FR were more often followed by an epileptiform spike, as compared with non-propagating FR (p < 0.05). Propagating FR had a distinct frequency and larger power (p < 1e-10) and were more strongly phase coupled to the peak of iEEG delta oscillation, which likely correspond with the DOWN states during non-REM sleep (p < 1e-8), than non-propagating FR. While FR propagation was rare, all FR occurred with the highest probability within +/- 400 msec of epileptiform spikes with superimposed high-frequency oscillations (p < 0.05). Thus, a sub-population of epileptiform spikes in the SOZ, are preceded by propagating FR that are coordinated by the DOWN state during non-REM sleep.
Volume
175
First Page
105928
Last Page
105928
ISSN
1095-953X
Published In/Presented At
Weiss, S. A., Sheybani, L., Seenarine, N., Fried, I., Wu, C., Sharan, A., Engel, J., Jr, Sperling, M. R., Nir, Y., & Staba, R. J. (2022). Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy. Neurobiology of disease, 175, 105928. https://doi.org/10.1016/j.nbd.2022.105928
Disciplines
Medicine and Health Sciences
PubMedID
36403895
Department(s)
Department of Surgery
Document Type
Article
