Brain atrophy in heart failure patients following left ventricular assist device implantation or heart transplantation.

Authors

D Alan Herbst
Banafsheh Shakibajahromi
Michael V Genuardi
Amit Iyengar
Dawn Mechanic-Hamilton
H Branch Coslett
Pavan Atluri MDFollow
Christopher G Favilla

Publication/Presentation Date

2-1-2025

Abstract

Advanced heart failure is associated with accelerated brain atrophy, largely related to chronic cerebral malperfusion. Both heart transplantation (HT) and left ventricular assist device (LVAD) implantation improve vital organ perfusion, but the comparative effect on brain atrophy remains unclear. Given the MR incompatibility of LVADs, we leveraged serial CT imaging in patients who underwent either HT or LVAD implantation. 58 patients were included in this single-center retrospective cohort (23 LVAD; 35 HT). LVAD patients experienced greater brain atrophy (median: 7.1 mL/year; IQR: 0.9-15.7) than transplant patients (median: 0.4 mL/year; IQR: -6.7-13.9), but this difference was non-significant (

Volume

7

First Page

100211

Last Page

100211

ISSN

2950-1334

Published In/Presented At

Herbst, D. A., Shakibajahromi, B., Genuardi, M. V., Iyengar, A., Mechanic-Hamilton, D., Branch Coslett, H., Atluri, P., & Favilla, C. G. (2025). Brain atrophy in heart failure patients following left ventricular assist device implantation or heart transplantation. JHLT open, 7, 100211. https://doi.org/10.1016/j.jhlto.2025.100211

Disciplines

Medicine and Health Sciences

PubMedID

40144844

Department(s)

Department of Surgery

Document Type

Article