Title

Early Atherogenesis and Visceral Fat in Obese Adolescents

Publication/Presentation Date

1-23-2014

Abstract

Background/Objectives:Little information is available as to the cause of increased thickening of the intima-media of the carotid artery (cIMT) in the pediatric population. Therefore, cIMT was compared in obese adolescents and normal-weight controls, and associations between cIMT and lipid and non-lipid cardiovascular risk factors were assessed.Subjects/Methods:Subjects included 61 obese non-diabetic male and female volunteers aged 12-18 years inclusive with a body mass index (BMI) >95th percentile for age and 2-h blood glucosedl(-1) matched to 25 normal-weight control volunteers with normal glucose levels. Each subject underwent a 2-h glucose tolerance test and measurement of hemoglobin A1c, ultrasensitive C-reactive protein, fasting insulin, blood lipids, visceral, subcutaneous abdominal and hepatic fat, and cIMT.Results:Maximum cIMT was 0.647±0.075 mm in the obese subjects versus 0.579±0.027 mm in normal-weight controls (P

Volume

38

Issue

7

First Page

954

Last Page

958

ISSN

1476-5497

Disciplines

Cardiology | Health and Medical Administration | Medical Specialties | Medicine and Health Sciences | Pediatrics | Radiology

PubMedID

24451186

Department(s)

Department of Pediatrics, Department of Pediatrics Faculty, Department of Radiology and Diagnostic Medical Imaging, Network Office of Research and Innovation

Document Type

Article