Early Atherogenesis and Visceral Fat in Obese Adolescents
Publication/Presentation Date
1-23-2014
Abstract
Background/Objectives:Little information is available as to the cause of increased thickening of the intima-media of the carotid artery (cIMT) in the pediatric population. Therefore, cIMT was compared in obese adolescents and normal-weight controls, and associations between cIMT and lipid and non-lipid cardiovascular risk factors were assessed.Subjects/Methods:Subjects included 61 obese non-diabetic male and female volunteers aged 12-18 years inclusive with a body mass index (BMI) >95th percentile for age and 2-h blood glucosedl(-1) matched to 25 normal-weight control volunteers with normal glucose levels. Each subject underwent a 2-h glucose tolerance test and measurement of hemoglobin A1c, ultrasensitive C-reactive protein, fasting insulin, blood lipids, visceral, subcutaneous abdominal and hepatic fat, and cIMT.Results:Maximum cIMT was 0.647±0.075 mm in the obese subjects versus 0.579±0.027 mm in normal-weight controls (P
Volume
38
Issue
7
First Page
954
Last Page
958
ISSN
1476-5497
Published In/Presented At
Slyper, A., Rosenberg, H., Kabra, A., Weiss, M., Blech, B., Gensler, S., & Matsumura, M. (2014). Early atherogenesis and visceral fat in obese adolescents. International Journal Of Obesity (2005), 38(7), 954-958. doi:10.1038/ijo.2014.11
Disciplines
Cardiology | Health and Medical Administration | Medical Specialties | Medicine and Health Sciences | Pediatrics | Radiology
PubMedID
24451186
LVHN link
http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=24451186&site=ehost-live&scope=site
Department(s)
Department of Pediatrics, Department of Pediatrics Faculty, Department of Radiology and Diagnostic Medical Imaging, Network Office of Research and Innovation
Document Type
Article