Guanabenz induced hypothermia in a poisoned elderly female.
Publication/Presentation Date
1-1-1994
Abstract
Guanabenz (Wytensin Wyeth-Ayerst Laboratories, Philadelphia, PA) is a centrally acting alpha 2 adrenergic agonist. Guanabenz shares structural and pharmacologic properties with the more commonly known sympatholytic agent clonidine. Little is known about guanabenz in overdose. Eleven cases of guanabenz poisoning have been reported in the literature and to the manufacturer to date and followed a clinical course comparable to clonidine poisoning. We report this case of guanabenz poisoning in an elderly woman who sustained protracted hypothermia following overdose. Hypothermia has been commonly associated with clonidine toxicity but has not been previously reported with guanabenz. Postulated mechanisms of clonidine induced hypothermia are discussed.
Volume
32
Issue
4
First Page
445
Last Page
449
ISSN
0731-3810
Published In/Presented At
Perrone, J., Hoffman, R. S., Jones, B., & Hollander, J. E. (1994). Guanabenz induced hypothermia in a poisoned elderly female. Journal of toxicology. Clinical toxicology, 32(4), 445–449. https://doi.org/10.3109/15563659409011047
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8057404
Department(s)
Administration and Leadership
Document Type
Article