Post-transplant Diabetes Mellitus in Kidney Transplant Recipients: A Multicenter Study.
Publication/Presentation Date
8-26-2021
Abstract
BACKGROUND:
METHODS: In a multicenter longitudinal cohort of 632 nondiabetic adult kidney recipients transplanted in 2010-2013, we ascertained outcomes through detailed chart review at 13 centers. We hypothesized that donor characteristics, such as sex, HCV infection, and kidney donor profile index (KDPI), and recipient characteristics, such as age, race, BMI, and increased HLA mismatches, would affect the development of PTDM among KT recipients. We defined PTDM as hemoglobin A1c ≥6.5%, pharmacological treatment for diabetes, or documentation of diabetes in electronic medical records. We assessed PTDM risk factors and evaluated for an independent time-updated association between PTDM and graft failure using regression.
RESULTS: Mean recipient age was 52±14 years, 59% were male, 49% were Black. Cumulative PTDM incidence 5 years post-KT was 29% (186). Independent baseline PTDM risk factors included older recipient age (
CONCLUSIONS: PTDM occurred commonly, and higher baseline BMI was associated with PTDM. PTDM was not associated with graft failure or mortality during the 6-year follow-up, perhaps due to the short follow-up time.
Volume
2
Issue
8
First Page
1296
Last Page
1307
ISSN
2641-7650
Published In/Presented At
Malik, R. F., Jia, Y., Mansour, S. G., Reese, P. P., Hall, I. E., Alasfar, S., Doshi, M. D., Akalin, E., Bromberg, J. S., Harhay, M. N., Mohan, S., Muthukumar, T., Schröppel, B., Singh, P., Weng, F. L., Thiessen Philbrook, H. R., & Parikh, C. R. (2021). Post-transplant Diabetes Mellitus in Kidney Transplant Recipients: A Multicenter Study. Kidney360, 2(8), 1296–1307. https://doi.org/10.34067/KID.0000862021
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
35369651
Department(s)
Administration and Leadership
Document Type
Article