Search for antibodies to galactocerebroside in the serum and cerebrospinal fluid in human demyelinating disorders.
Publication/Presentation Date
9-1-1987
Abstract
To determine if galactocerebroside (GalC) is a target antigen in the human demyelinating disorders multiple sclerosis, Guillain-Barré syndrome, and chronic demyelinating inflammatory polyneuropathy, we examined the serum and cerebrospinal fluid from patients with these disorders and from control subjects using four assay systems. In none of these assays could we detect significant differences in anti-GalC antibody titer between patients with demyelinating diseases and normal subjects or patients with other neurological disorders. Our data suggest that there is no humoral immune response to GalC in human demyelinating disorders.
Volume
22
Issue
3
First Page
381
Last Page
383
ISSN
0364-5134
Published In/Presented At
Rostami, A. M., Burns, J. B., Eccleston, P. A., Manning, M. C., Lisak, R. P., & Silberberg, D. H. (1987). Search for antibodies to galactocerebroside in the serum and cerebrospinal fluid in human demyelinating disorders. Annals of neurology, 22(3), 381–383. https://doi.org/10.1002/ana.410220316
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3674803
Department(s)
Administration and Leadership
Document Type
Article