Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1).
Publication/Presentation Date
9-1-2011
Abstract
To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 genes were significantly associated with ALL risk at the P < 0.05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P = 3 × 10(-5)]. In addition, a major haplotype within LMO1 comprising 14 SNPs with individual risk associations was found to significantly increase ALL risk (OR = 1.79, P = 0.0006). A stratified analysis on subtype indicated that risk associations of LMO1 variants are significant in children with precursor B-cell leukemia. These data show that genetic variants within LMO1 are associated with ALL and identify this gene as a strong candidate for precursor B-cell leukemogenesis.
Volume
32
Issue
9
First Page
1349
Last Page
1353
ISSN
1460-2180
Published In/Presented At
Beuten, J., Gelfond, J. A., Piwkham, D., Pollock, B. H., Winick, N. J., Collier, A. B., 3rd, & Tomlinson, G. E. (2011). Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1). Carcinogenesis, 32(9), 1349–1353. https://doi.org/10.1093/carcin/bgr091
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
21602560
Department(s)
Department of Pediatrics
Document Type
Article