Changing sensitivity of the pubertal gonadal hypothalamic feedback mechanism in man.
Publication/Presentation Date
11-21-1969
Abstract
Clomiphene citrate in doses which stimulate gonadotropin production in the adult suppresses urinary follicle stimulating hormone (FSH) excretion and plasma testosterone concentration in prepubertal children. Such results indicate that feedback between gonad and hypothalamus is operative and highly sensitive in prepubertal humans. Puberty in man, as in the rat, is accompanied by a decrease in the sensitivity of the feedback mechanism.
Volume
166
Issue
3908
First Page
1012
Last Page
1013
ISSN
0036-8075
Published In/Presented At
Kulin, H. E., Grumbach, M. M., & Kaplan, S. L. (1969). Changing sensitivity of the pubertal gonadal hypothalamic feedback mechanism in man. Science (New York, N.Y.), 166(3908), 1012–1013. https://doi.org/10.1126/science.166.3908.1012
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
4899830
Department(s)
Department of Pediatrics
Document Type
Article