Plasma testosterone response to short-term human chorionic gonadotropin administration in men with follicle-stimulating hormone suppressed by exogenous estrogen.
Publication/Presentation Date
4-1-1975
Abstract
In order to investigate the role of FSH in Leydig cell function, six men were given four daily injections of HCG (4,000 IU) while receiving oral ethinyl estradiol. The peak testosterone levels in these subjects were contrasted to the results obtained in seven men who received HCG without additional exogenous steroid treatment. Urinary and plasma FSH was suppressed to 26% and 50%, respectively, of basal values by the estrogen treatment. Peak plasma testosterone determinations following HCG did not differ in the two groups of subjects. Additionally, an early pubertal boy had a normal HCG-induced testosterone rise while his urinary FSH was suppressed by estradiol to lower than prepubertal levels. The data indicate the short-term FSH suppression does not alter testicular responsivity to short-term HCG administration. A role for FSH in Leydig cell testosterone production in men has yet to be demonstrated.
Volume
26
Issue
4
First Page
340
Last Page
345
ISSN
0015-0282
Published In/Presented At
Reiter, E. O., & Kulin, H. E. (1975). Plasma testosterone response to short-term human chorionic gonadotropin administration in men with follicle-stimulating hormone suppressed by exogenous estrogen. Fertility and sterility, 26(4), 340–345. https://doi.org/10.1016/s0015-0282(16)41055-1
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
1116629
Department(s)
Department of Pediatrics
Document Type
Article