Timed urinary gonadotropin measurements in normal infants, children, and adults, and in patients with disorders of sexual maturation.
Publication/Presentation Date
5-1-1977
Abstract
Timed urine collections-mostly over a three-hour period-were obtained from 58 newborn, 68 prepubertal children, 27 adolescents, and 51 adults. For comparison, similar samples were collected from 69 patients with presumptive abnormalities of sexual maturation. Follicle-stimulating hormone and luteinizing hormone were extracted by acetone precipitation and measured by radioimmunossay. Adult nem and women excreted approximately 11 times as much FSH and 33 times as much LH as perpubertal children. Elevated and/or diminished excretory values of gonadotropins were associated with appropriate diagnoses of abnormal pubertal advance or delay. Timed urinary FSH and LH measurements can provide a simple, sensitive, and accurate test of gonadotropin function in children.
Volume
90
Issue
5
First Page
760
Last Page
765
ISSN
0022-3476
Published In/Presented At
Kulin, H. E., & Santner, S. J. (1977). Timed urinary gonadotropin measurements in normal infants, children, and adults, and in patients with disorders of sexual maturation. The Journal of pediatrics, 90(5), 760–765. https://doi.org/10.1016/s0022-3476(77)81243-2
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
856964
Department(s)
Department of Pediatrics
Document Type
Article