The effect of growth hormone on the Leydig cell response to chorionic gonadotrophin in boys with hypopituitarism.
Publication/Presentation Date
11-1-1981
Abstract
Eleven boys with growth hormone (hGH) deficiency received human chorionic gonadotrophin (hCG) stimulation tests for the assessment of Leydig cell function before, during, and after 1 year of treatment with somatotrophin. Two patients entered puberty during the course of the study protocol. Analysis of the data in nine prepubertal boys revealed an augmentation of testosterone (T) responses to hCG in the presence of hGH. In six of these individuals in whom dihydrotestosterone (DHT) was determined, a similar augmentation in responsiveness of this steroid was found in the presence of hGH. Three prepubertal boys exhibited poor T responses to the basal hCG test with only partial improvement following hGH. In man growth hormone may be an important permissive factor in Leydig cell activity during periods of changing testicular function such as occur in utero or during puberty.
Volume
15
Issue
5
First Page
463
Last Page
472
ISSN
0300-0664
Published In/Presented At
Kulin, H. E., Samojlik, E., Santen, R., & Santner, S. (1981). The effect of growth hormone on the Leydig cell response to chorionic gonadotrophin in boys with hypopituitarism. Clinical endocrinology, 15(5), 463–472. https://doi.org/10.1111/j.1365-2265.1981.tb00689.x
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
7326847
Department(s)
Department of Pediatrics
Document Type
Article