Response of the prepubertal ovary to acute chorionic gonadotropin administration: absence of modulation by growth hormone.
Publication/Presentation Date
1-1-1985
Abstract
Twenty-five short term hCG stimulation tests were performed in seven prepubertal girls, aged 3-11 yr, who were being evaluated for short stature. Provocative testing revealed GH deficiency in all patients, but reevaluation of one girl at a later date showed normal somatotropin levels. The study protocol lasted 18 months and included testing before, during, and after 1 yr of GH therapy. Delta 4-Androstenedione, testosterone, estrone, and estradiol were determined 0, 24, 48, and 72 h after initiation of a two-injection course of CG. Significant responses (approximately 2-fold over baseline) to the stimulation tests occurred for all steroids except testosterone, though no augmented effects were found in the presence of human GH. The results indicate functional capability of the prepubertal ovary when exposed acutely to a LH-like material, but no role for somatotropin in gonadal steroid production in the prepubertal female.
Volume
60
Issue
1
First Page
208
Last Page
211
ISSN
0021-972X
Published In/Presented At
Kulin, H. E., Samojlik, E., Demers, L. M., & Santner, S. J. (1985). Response of the prepubertal ovary to acute chorionic gonadotropin administration: absence of modulation by growth hormone. The Journal of clinical endocrinology and metabolism, 60(1), 208–211. https://doi.org/10.1210/jcem-60-1-208
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
3917268
Department(s)
Department of Pediatrics
Document Type
Article