Estrogen or testosterone increases self-reported aggressive behaviors in hypogonadal adolescents.
Publication/Presentation Date
8-1-1997
Abstract
A randomized, double-blinded, placebo-controlled cross-over clinical trial was used to determine the role of sex steroids on the development of aggressive behaviors in 35 boys and 14 girls. Depo-testosterone (to boys) or conjugated estrogens (to girls) was administered in 3-month blocks alternating with placebo at three dose levels approximating early, middle and late pubertal amounts. The Olweus Multifaceted Aggression Inventory was administered after each placebo and treatment period to ascertain the effect of sex steroids on self-reported aggressive behaviors. We employed a strict intent-to-treat analytical model. The data demonstrated significant hormone effects on physical aggressive behaviors and aggressive impulses, but not in verbal aggressive behaviors nor aggressive inhibitions in both boys and girls. These results are the first to causally relate the administration of physiological doses of sex steroids to changes in aggressive behaviors in adolescents.
Volume
82
Issue
8
First Page
2433
Last Page
2438
ISSN
0021-972X
Published In/Presented At
Finkelstein, J. W., Susman, E. J., Chinchilli, V. M., Kunselman, S. J., D'Arcangelo, M. R., Schwab, J., Demers, L. M., Liben, L. S., Lookingbill, G., & Kulin, H. E. (1997). Estrogen or testosterone increases self-reported aggressive behaviors in hypogonadal adolescents. The Journal of clinical endocrinology and metabolism, 82(8), 2433–2438. https://doi.org/10.1210/jcem.82.8.4165
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
9253313
Department(s)
Department of Pediatrics
Document Type
Article