The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report.
Publication/Presentation Date
1-1-1976
Abstract
Administration of anticonvulsant medication to recipients of cadaver renal allografts appears to be associated with decreased allograft survival. The one-and two-year actuarial graft survival rates for 20 index grafts was significantly lower than for 92 control grafts. Since phenobarbital and diphenylhydantoin increase the metabolism of corticosteroids, it is proposed that renal allograft recipients receiving these anticonvulsants may have ineffective immunosuppression, leading to a higher incidence of graft failure.
Volume
88
Issue
1
First Page
134
Last Page
137
ISSN
0022-3476
Published In/Presented At
Wassner, S. J., Pennisi, A. J., Malekzadeh, M. H., & Fine, R. N. (1976). The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report. The Journal of pediatrics, 88(1), 134–137. https://doi.org/10.1016/s0022-3476(76)80745-7
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
1107499
Department(s)
Department of Pediatrics
Document Type
Article