Thyroid function in children with chronic renal failure.
Publication/Presentation Date
1-1-1977
Abstract
Thyroid function was evaluated in 24 children (aged 4-18 years) with chronic renal failure either before institution of hemodialysis or after more than 3 months of hemodialysis. 22 patients were clinically euthyroid and 2 were hypothyroid; in one case hypothyroidism was secondary to cystinosis and in the other it followed radiation therapy. The 2 hypothyroid patients had subnormal levels of T4, T3, FTI and FT4 as well as elevated serum TSH levels. Mean values for T4, T3, FTI and FT4 for the remaining 22 patients were within the normal range, but were significantly decreased, (all p values less than 0.01) when compared to controls. TSH and TBG levels were not significantly different from those of the normal population. Eleven of the euthyroid patients (50%) had either T3 or FT4, but not both, below the normal range without elevation of their TSH levels. These findings suggest that in the absence of other causes of hypothyroidism, children with chronic renal failure are able to maintain a clinically euthyroid state with either normal FT4 or T3 serum levels and can respond to primary gland failure with elevated TSH secretion.
Volume
19
Issue
4
First Page
236
Last Page
241
ISSN
1660-8151
Published In/Presented At
Wassner, S. J., Buckingham, B. A., Kershnar, A. J., Malekzadeh, M. H., Pennisi, A. J., & Fine, R. N. (1977). Thyroid function in children with chronic renal failure. Nephron, 19(4), 236–241. https://doi.org/10.1159/000180894
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
917171
Department(s)
Department of Pediatrics
Document Type
Article