Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.
Publication/Presentation Date
7-1-1983
Abstract
The myopathy associated with vitamin D deficiency was examined in vitamin D-deficient and vitamin D-supplemented rats. When compared with either vitamin D-supplemented ad lib. or pair-fed rats, weight gain and muscle mass were decreased in vitamin D-deficient hypocalcemic animals. With the exception of a modest decrease in muscle creatine phosphate levels, muscle composition was unchanged by vitamin D deficiency. Muscle protein turnover rates were determined in both in vivo and in vitro studies and demonstrated that myofibrillar protein degradation was increased in vitamin D deficiency. Normal growth rates could be maintained be feeding the rats vitamin D-deficient diets containing 1.6% calcium, which maintained plasma calcium within the normal range. In addition to its role in maintaining plasma calcium, vitamin D-supplemented rats had significantly higher levels of the anabolic hormone insulin. Vitamin D supplementation may affect muscle protein turnover by preventing hypocalcemia, as well as directly stimulating insulin secretion, rather than by a direct effect within skeletal muscle.
Volume
72
Issue
1
First Page
102
Last Page
112
ISSN
0021-9738
Published In/Presented At
Wassner, S. J., Li, J. B., Sperduto, A., & Norman, M. E. (1983). Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats. The Journal of clinical investigation, 72(1), 102–112. https://doi.org/10.1172/jci110947
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
6308041
Department(s)
Department of Pediatrics
Document Type
Article