Familial lobular glomerulopathy.
Publication/Presentation Date
8-1-1991
Abstract
A family with an unusual lobular glomerulopathy is described. Renal tissue from three males and one female in two successive generations was available for review. The glomerulopathy was characterized by a marked lobular accentuation with only a modest increase in mesangial cellularity. Immunofluorescence in two patients showed focal or diffuse staining with immunoglobulins G, A, M, and C3 in the mesangium and along the glomerular capillary basement membranes. Ultrastructural study showed amorphous granular subendothelial material distending capillary loops and mesangial regions. This material accounted for the pronounced lobular accentuation. The patients in this family presented with proteinuria, hematuria, and hypertension. Three of the four patients have sustained cerebral vascular accidents and two have died. This family is compared with a previously reported family that showed similar glomerular pathology.
Volume
22
Issue
8
First Page
825
Last Page
829
ISSN
0046-8177
Published In/Presented At
Abt, A. B., Wassner, S. J., & Moran, J. J. (1991). Familial lobular glomerulopathy. Human pathology, 22(8), 825–829. https://doi.org/10.1016/0046-8177(91)90212-8
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
1869266
Department(s)
Department of Pediatrics
Document Type
Article