Recurrent seizures in a neonate after lidocaine administration.
Publication/Presentation Date
1-1-1998
Abstract
OBJECTIVE: We report recurrent seizures in a neonate after intravenous lidocaine administration at the recommended dose for intubation and supplementation of general anesthesia.
STUDY DESIGN: Further evaluation of this case included determination of serum lidocaine level, serum electrolyte levels, and arterial blood gas values; cerebral spinal fluid analysis; an electroencephalogram; head ultrasonography; brain stem auditory evoked response testing; and a complete developmental evaluation. Previously published literature discussing lidocaine toxicity and pharmacokinetics is reviewed.
RESULTS: The lidocaine level in the patient was 0.3 mg/L 2 hours after the last dose was administered. Results of the remaining studies were within normal limits, and the patient had no additional seizures several months after birth.
CONCLUSION: We caution that lidocaine administration to newborn infants at previously accepted doses may result in life-threatening side effects, including prolonged seizures.
Volume
18
Issue
3
First Page
193
Last Page
195
ISSN
0743-8346
Published In/Presented At
Resar, L. M., & Helfaer, M. A. (1998). Recurrent seizures in a neonate after lidocaine administration. Journal of perinatology : official journal of the California Perinatal Association, 18(3), 193–195.
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
9659647
Department(s)
Department of Pediatrics
Document Type
Article