Improved relapse-free survival in medulloblastoma utilizing modern techniques.
Publication/Presentation Date
12-1-1981
Abstract
Between 1969 and 1979, 22 patients with medulloblastoma were treated by the same surgical group and radiation therapy group. The patients were divided into two groups because of the clinical availability in December 1974 of the computed tomographic (CT) scanner and of the operating microscope used in the initial surgical procedure. There were 11 patients in each group. The percentage of patients with a relapse-free survival in the group treated between 1969 and 1974 (Group 1) was 38% at 4 years. The survival in the 11 patients treated between 1974 and 1979 (Group 2) was 84% at 4 years. This improvement is statistically significant (P less than or equal to 0.001). All patients received the same dose of radiation. Efforts to minimize the tumor burden by total surgical resection did not increase postoperative morbidity or mortality. These results are discussed, along with the relative impact of the CT scan, total resection at operation, and increased focus for radiation therapy on the improved outcome.
Volume
9
Issue
6
First Page
661
Last Page
664
ISSN
0148-396X
Published In/Presented At
Norris, D. G., Bruce, D. A., Byrd, R. L., Schut, L., Littman, P., Bilaniuk, L. T., Zimmerman, R. A., & Capp, R. (1981). Improved relapse-free survival in medulloblastoma utilizing modern techniques. Neurosurgery, 9(6), 661–664. https://doi.org/10.1227/00006123-198112000-00008
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
7322331
Department(s)
Department of Pediatrics
Document Type
Article