Experimental intracranial septic infarction: magnetic resonance enhancement.
Publication/Presentation Date
6-1-1985
Abstract
Intracranial brain abscess was produced in three monkeys by embolization of a small pledget of polyvinyl alcohol (PVA) soaked in a broth of Staphylococcus aureus. Imaging of the chronic stable abscess was performed on the General Electric 8800 CT unit (Milwaukee, Wis.) and a 1.4 T superconducting small bore imaging system. Magnetic resonance imaging included saturation recovery, inversion recovery, and spin echo techniques. MR imaging was also performed after paramagnetic enhancement using gadolinium-DPTA (Gd-DTPA). Our results show that paramagnetic enhancement with T1-weighted imaging adds specificity and enables rapid assessment of abnormalities of the blood-brain barrier. T2-weighted imaging without paramagnetic enhancement was very sensitive in defining areas of abnormality in the brain but in our experiment lacked specificity. T2-weighted imaging with Gd-DTPA demonstrated no obvious change in the appearance of the lesion. The combination of T1-weighted Gd-DTPA and T2-weighted imaging appeared complementary in our experiment, and these images correlated well with the pathologic findings.
Volume
155
Issue
3
First Page
649
Last Page
653
ISSN
0033-8419
Published In/Presented At
Grossman, R. I., Joseph, P. M., Wolf, G., Biery, D., McGrath, J., Kundel, H. L., Fishman, J. E., Zimmerman, R. A., Goldberg, H. I., & Bilaniuk, L. T. (1985). Experimental intracranial septic infarction: magnetic resonance enhancement. Radiology, 155(3), 649–653. https://doi.org/10.1148/radiology.155.3.4001365
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
4001365
Department(s)
Department of Pediatrics
Document Type
Article