High-field magnetic resonance imaging of Wilson's disease.
Publication/Presentation Date
4-1-1987
Abstract
A single case of Wilson's hepatolenticular degeneration was imaged by computed tomography and magnetic resonance (1.5 Tesla). Findings included generalized cerebral atrophy seen both on computed tomography and magnetic resonance images. T1-weighted images revealed a slight symmetric hypointensity in the lentiform nuclei and thalamus. T2-weighted images demonstrated marked symmetric hypointensity in the lentiform nuclei. These hypointensities are ascribed to the deposition of intracellular hemosiderin (and perhaps copper), which produce heterogeneous magnetic susceptibility and preferential T2-proton relaxation. Areas of increased signal activity on T2-weighted images were also seen in areas of presumed demyelination known to occur in Wilson's disease.
Volume
11
Issue
2
First Page
132
Last Page
135
ISSN
0149-936X
Published In/Presented At
De Haan, J., Grossman, R. I., Civitello, L., Hackney, D. B., Goldberg, H. I., Bilaniuk, L. T., & Zimmerman, R. A. (1987). High-field magnetic resonance imaging of Wilson's disease. The Journal of computed tomography, 11(2), 132–135. https://doi.org/10.1016/0149-936x(87)90004-x
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
3581846
Department(s)
Department of Pediatrics
Document Type
Article