MR imaging of tuberous sclerosis: pathogenesis of this phakomatosis, use of gadopentetate dimeglumine, and literature review.
Publication/Presentation Date
4-1-1992
Abstract
Findings on cranial magnetic resonance (MR) images were correlated with known histopathologic findings in 42 patients with tuberous sclerosis (TS), 17 of whom received gadopentetate dimeglumine, to extend the range of signs on MR images. Four neuroradiologists recorded the number, sites, configurations, and relative signal intensities of intracranial abnormalities. White matter lesions, found in 39 patients (93%), showed four distinct patterns: (a) straight or curvilinear bands extending radially from the ventricle through the cerebral mantle toward the cortex, (b) wedge-shaped lesions, (c) nonspecific conglomerate foci, and (d) cerebellar radial bands. It is concluded that cortical tubers, white matter lesions, subependymal nodules, and sub-ependymal giant cell astrocytomas (SGCAs) may be enhanced after administration of gadopenetetate dimeglumine. Enhancement of a TS lesion does not indicate neoplastic transformation into SGCA. Imaging surveillance every 12 months appears indicated during the peak ages (8-18 years) of occurrence of SGCA. The appearance of white matter lesions supports the theory that the cerebral lesions of TS may be caused by disordered migration of dysgenetic cells.
Volume
183
Issue
1
First Page
227
Last Page
238
ISSN
0033-8419
Published In/Presented At
Braffman, B. H., Bilaniuk, L. T., Naidich, T. P., Altman, N. R., Post, M. J., Quencer, R. M., Zimmerman, R. A., & Brody, B. A. (1992). MR imaging of tuberous sclerosis: pathogenesis of this phakomatosis, use of gadopentetate dimeglumine, and literature review. Radiology, 183(1), 227–238. https://doi.org/10.1148/radiology.183.1.1549677
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
1549677
Department(s)
Department of Pediatrics
Document Type
Article