Differential development of umbilical and systemic arteries. II. Contractile proteins.
Publication/Presentation Date
6-1-1998
Abstract
In fetal sheep, umbilical responsiveness to ANG II exceeds systemic vascular responsiveness. Fetal systemic vascular smooth muscle (VSM) exhibits an immature phenotype with decreased contractile protein contents, low 200-kDa myosin heavy chain (MHC) SM2, and significant nonmuscle MHC-B expression, whereas umbilical VSM phenotype is incompletely described. We tested the hypothesis that differences in vascular responsiveness could reflect dissimilarities in VSM phenotype. Actin, MHC, MHC isoforms, and active stresses were compared in strips of femoral arteries and aorta from near-term fetal (n = 12) and adult (n = 12) sheep to those in external and intra-abdominal umbilical arteries. Actin contents in fetal femoral artery and aorta were less (P
Volume
274
Issue
6
First Page
1815
Last Page
1823
ISSN
0002-9513
Published In/Presented At
Arens, Y., Chapados, R. A., Cox, B. E., Kamm, K. E., & Rosenfeld, C. R. (1998). Differential development of umbilical and systemic arteries. II. Contractile proteins. The American journal of physiology, 274(6), R1815–R1823. https://doi.org/10.1152/ajpregu.1998.274.6.R1815
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
9841554
Department(s)
Department of Pediatrics
Document Type
Article