Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.
Publication/Presentation Date
1-1-1995
Abstract
G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRK5 (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24-->qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter-->q21.
Volume
70
Issue
3-4
First Page
250
Last Page
254
ISSN
0301-0171
Published In/Presented At
Bullrich, F., Druck, T., Kunapuli, P., Gomez, J., Gripp, K. W., Schlegelberger, B., Lasota, J., Aronson, M., Cannizzaro, L. A., & Huebner, K. (1995). Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6. Cytogenetics and cell genetics, 70(3-4), 250–254. https://doi.org/10.1159/000134045
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
7789183
Department(s)
Department of Pediatrics
Document Type
Article