Cadherin-mediated cell-cell adhesion: sticking together as a family.
Publication/Presentation Date
12-1-2003
Abstract
The cadherins comprise a family of single-pass transmembrane proteins critical for cell-cell adhesion in vertebrates and invertebrates. The recently determined structure of the whole ectodomain from C-cadherin suggests that the adhesion of cadherins presented by juxtaposed cells is mediated by a strand-swapped dimer in which core hydrophobic elements are exchanged between the partner molecules. Sequence analysis suggests that several cadherin subfamilies share this adhesive mechanism. Recent work has shed new light on the molecular basis of cadherin adhesion, although understanding the specificity of these interactions remains a major challenge.
Volume
13
Issue
6
First Page
690
Last Page
698
ISSN
0959-440X
Published In/Presented At
Patel, S. D., Chen, C. P., Bahna, F., Honig, B., & Shapiro, L. (2003). Cadherin-mediated cell-cell adhesion: sticking together as a family. Current opinion in structural biology, 13(6), 690–698. https://doi.org/10.1016/j.sbi.2003.10.007
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
14675546
Department(s)
Department of Pediatrics
Document Type
Article