Improved Side Effect Profile of Alternate-Day Dosing of Lenalidomide.
Publication/Presentation Date
3-1-2024
Abstract
Myelodysplastic syndrome (MDS) is a heterogeneous hematological condition associated with cytopenia, inadequate blood cell synthesis, and the risk of developing acute myeloid leukemia (AML). Patients are divided into risk groups according to the International Prognostic Scoring System (IPSS) to help direct therapy. Allogeneic stem cell transplantation, despite its limitations, is curative. Medical management, such as the use of lenalidomide, has potential benefits but can cause adverse effects that require dose regimen modification. Lenalidomide is approved for low-risk MDS with 5q deletion (5q- MDS). In this case study, a 79-year-old woman with 5q- MDS was switched from a daily regimen to an alternate-day lenalidomide dose schedule to achieve complete remission with fewer adverse effects. The management of hematological toxicity and the mechanisms of action of lenalidomide are discussed. We recommend individualized treatment strategies and additional research to improve MDS management.
Volume
16
Issue
3
First Page
55317
Last Page
55317
ISSN
2168-8184
Published In/Presented At
Lawal, R. A., Banjoko, O., Ndulue, C., Adebeshin, S. T., Sharif, A., Ighodaro, O. E., Olusoji, R., Odusanya, B., & El-Hamdi, N. S. (2024). Improved Side Effect Profile of Alternate-Day Dosing of Lenalidomide. Cureus, 16(3), e55317. https://doi.org/10.7759/cureus.55317
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
38559519
Department(s)
Department of Pediatrics, Department of Pediatrics Residents, Fellows and Residents
Document Type
Article