Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study.
Publication/Presentation Date
1-15-1991
Abstract
Brain morphology was examined using magnetic resonance imaging in 30 first-episode patients with a schizophreniclike psychosis, 15 chronic schizophrenics, and 20 neurological controls. Statistical analyses of computer-generated measurements of regions of interest were controlled for gender, age, social class, and total brain volume. Lateral ventricular size was increased in both first-episode and chronic schizophrenic patients, with greater significance on the left than on the right side. Only the chronic patients, however, had reduced temporal lobe size, which also was greater on the left side. No major correlations of regional brain morphological measurements with cognitive functioning were found, although some measurements of verbal memory were correlated with parahippocampal size. This is a report of a preliminary study that suggests that some morphological brain changes may be present at the time of first treatment for a psychotic illness, whereas others may occur later in the course of illness. Future prospective studies may determine the clinical significance of these changes and whether they progress with the development of illness chronicity.
Volume
29
Issue
2
First Page
159
Last Page
175
ISSN
0006-3223
Published In/Presented At
DeLisi, L. E., Hoff, A. L., Schwartz, J. E., Shields, G. W., Halthore, S. N., Gupta, S. M., Henn, F. A., & Anand, A. K. (1991). Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biological psychiatry, 29(2), 159–175. https://doi.org/10.1016/0006-3223(91)90044-m
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
1995085
Department(s)
Department of Pediatrics
Document Type
Article