Renal adaptation to extrauterine life in patients with respiratory distress syndrome.
Publication/Presentation Date
10-1-1985
Abstract
A spontaneous diuresis that precedes the improvement of pulmonary function has been described in patients with respiratory distress syndrome (RDS). The developmental changes in renal physiology responsible for this spontaneous diuresis are not completely understood. To describe the mechanisms responsible for the spontaneous diuresis, serial renal function studies were performed during the first five days of life in nine premature neonates with RDS. Diuresis was defined as a urine output that was at least 80% of fluid intake; prediuretic, diuretic, and postdiuretic periods were observed in all study infants. Oxygenation did not improve until the postdiuretic period. Renal function studies disclosed a significant increase in free water clearance during the diuresis with the production of dilute urine and a reciprocal rise in serum sodium concentration and plasma osmolality. The glomerular filtration rate increased at the onset of diuresis and remained elevated after the diuresis ended; however, the proportion of filtrate excreted was significantly elevated during the diuresis compared with prediuretic and postdiuretic values. These data suggest that the diuresis in patients with RDS is a water diuresis secondary to an endogenous water load.
Volume
139
Issue
10
First Page
1060
Last Page
1063
ISSN
0002-922X
Published In/Presented At
Costarino, A. T., Baumgart, S., Norman, M. E., & Polin, R. A. (1985). Renal adaptation to extrauterine life in patients with respiratory distress syndrome. American journal of diseases of children (1960), 139(10), 1060–1063. https://doi.org/10.1001/archpedi.1985.02140120106039
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
4036895
Department(s)
Department of Pediatrics
Document Type
Article