The dose-response relationship for hypoxic pulmonary vasoconstriction.
Publication/Presentation Date
5-1-1994
Abstract
In 12 pentobarbital anesthetized dogs the lungs were independently ventilated with a double piston ventilator. The right lung was ventilated throughout with 100% oxygen. Blood was drawn from the right atrium and pumped through a bubble oxygenator to a cannula in the ligated left main pulmonary artery. The pressures in the left main pulmonary artery and the left atrium were recorded during constant flow while the oxygen tension in the left lung alveolar gas and the perfusate were varied either to match each other (Protocol 1) or differ (Protocol 2) over the range from "zero" to "100%" oxygen. From the combined data a three dimensional response surface for hypoxic pulmonary vasoconstriction was derived. The maximum increase of pulmonary vascular resistance (r%PVRmax) was defined at a stimulus oxygen tension (PSO2) of 10 mmHg amounting to a 3.15 +/- (0.18)-fold increase of the vascular resistance on "100%" oxygen. The stimulus oxygen tension was shown to be PSO2 = PVO2(0.41) x PAO2(0.59) and the dose-response sigmoid for hypoxic pulmonary vasoconstriction in canine lungs was derived as r%PVRmax = 100 (PSO2(-2.616))/(6.683 x 10(-5) + PSO2(-2.616)) These results appear to reconcile observations from a number of laboratories and to be of quite general application.
Volume
96
Issue
2-3
First Page
231
Last Page
247
ISSN
0034-5687
Published In/Presented At
Marshall, B. E., Clarke, W. R., Costarino, A. T., Chen, L., Miller, F., & Marshall, C. (1994). The dose-response relationship for hypoxic pulmonary vasoconstriction. Respiration physiology, 96(2-3), 231–247. https://doi.org/10.1016/0034-5687(94)90129-5
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
8059086
Department(s)
Department of Pediatrics
Document Type
Article