Animal models of atopic dermatitis.
Publication/Presentation Date
1-1-2009
Abstract
Atopic dermatitis (AD) is characterized by allergic skin inflammation. A hallmark of AD is dry itchy skin due, at least in part, to defects in skin genes that are important for maintaining barrier function. The pathogenesis of AD remains incompletely understood. Since the description of the Nc/Nga mouse as a spontaneously occurring model of AD, a number of other mouse models of AD have been developed. They can be categorized into three groups: (1) models induced by epicutaneous application of sensitizers; (2) transgenic mice that either overexpress or lack selective molecules; (3) mice that spontaneously develop AD-like skin lesions. These models have resulted in a better understanding of the pathogenesis of AD. This review discusses these models and emphasizes the role of mechanical skin injury and skin barrier dysfunction in eliciting allergic skin inflammation.
Volume
129
Issue
1
First Page
31
Last Page
40
ISSN
1523-1747
Published In/Presented At
Jin, H., He, R., Oyoshi, M., & Geha, R. S. (2009). Animal models of atopic dermatitis. The Journal of investigative dermatology, 129(1), 31–40. https://doi.org/10.1038/jid.2008.106
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
19078986
Department(s)
Department of Pediatrics
Document Type
Article