"Intussusception in an infant with acute lymphoblastic leukemia: a case" by M V Manglani, J Rosenthal et al.
 

Intussusception in an infant with acute lymphoblastic leukemia: a case report and review of the literature.

Publication/Presentation Date

1-1-1998

Abstract

PURPOSE: An ileocecal intussusception developed in a 7-month-old infant with acute lymphoblastic leukemia (ALL) during induction therapy. Gastrointestinal complications, especially intussusception, are rare in children with ALL.

PATIENT AND METHODS: The history of a 7-month-old white boy with ALL in whom an ileocecal intussusception developed 1 week into induction chemotherapy was reviewed. In addition, a literature search was performed to determine the prevalence of this complication in children with acute leukemia.

RESULTS: On day 4 of induction chemotherapy for B-lineage ALL, the infant developed abdominal distension with hypoactive bowel sounds. After a barium enema and abdominal computed tomography scan, the symptoms were determined to be caused by an ileocecal intussusception. Chemotherapy was resumed 1 week after immediate surgical intervention (reduction of intussusception and resection of the "leading edge") with an uneventful post-operative recovery. Histopathologic examination of the resected edge revealed an intact mucosa with areas of necrosis in the submucosa. This was associated with a dense lymphoid infiltrate composed of mature lymphocytes and leukemic cells, edema, and focal necrosis. Despite a 1-week delay in chemotherapy, a complete remission was documented at day 32.

DISCUSSION: The prevalence of intussusception in children with ALL and its possible etiology are discussed. The pathologic changes, clinical manifestations, and treatment outcome are briefly mentioned.

Volume

20

Issue

5

First Page

467

Last Page

468

ISSN

1077-4114

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

9787321

Department(s)

Department of Pediatrics

Document Type

Article

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