Adolescents and young adults with cancer: the clinical course of COVID-19 infections.
Publication/Presentation Date
8-1-2024
Abstract
Adolescents and young adults (ie, individuals aged 15-39 years, known as AYAs) with cancer face unique vulnerabilities yet remain underrepresented in clinical trials, including adult registries of COVID-19 in cancer (AYAs: 8%-12%). We used the Pediatric Oncology COVID-19 Case Report to examine the clinical course of COVID-19 among AYAs with cancer. The Pediatric Oncology COVID-19 Case Report collects deidentified clinical and sociodemographic data regarding individuals aged from birth to 39 years with cancer (37%) and COVID-19 from more than 100 institutions. Between April 1, 2020, and November 28, 2023, 191 older AYAs (individuals 22-39 years of age) and 640 younger AYAs (individuals 15-21 years of age) were captured. Older AYAs were less often hospitalized (P < .001), admitted to the intensive care unit (P = .02), and required respiratory support (P = .057). In multivariable analyses, older AYAs faced 80% lower odds of intensive care unit admission but 2.3-times greater odds of changes to cancer-directed therapy. Unvaccinated patients had 5.4-times higher odds of intensive care unit admission. Among AYAs with cancer, the COVID-19 course varies by age. These findings can inform oncology teams directing COVID-19 management and prevention in AYA patients with cancer.
Volume
116
Issue
8
First Page
1366
Last Page
1373
ISSN
1460-2105
Published In/Presented At
Wolfson, J. A., Davis, E. S., Saha, A., Martinez, I., McCall, D., Kothari, P., Brackett, J., Dickens, D. S., Kahn, A. R., Schwalm, C., Sharma, A., Richman, J., Cuglievan, B., POCC Consortium, Bhatia, S., Dai, C., Levine, J. M., & Johnston, E. E. (2024). Adolescents and young adults with cancer: the clinical course of COVID-19 infections. Journal of the National Cancer Institute, 116(8), 1366–1373. https://doi.org/10.1093/jnci/djae085
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
38627241
Department(s)
Department of Pediatrics
Document Type
Article
