Validating the M. D. Anderson Symptom Inventory (MDASI) for use in patients with ovarian cancer.
Publication/Presentation Date
8-1-2013
Abstract
OBJECTIVE: The M. D. Anderson Symptom Inventory (MDASI) captures the severity of common cancer symptoms from the patient's perspective. We describe the validity and sensitivity of a module of the MDASI to be used with patients having ovarian cancer (MDASI-OC).
METHODS: Ovarian cancer-specific module items were developed from 14 qualitative patient interviews. 128 patients with invasive epithelial ovarian, peritoneal, or fallopian-tube cancer treated at The University of Texas MD Anderson Cancer Center were recruited. Patients completed the MDASI-OC, socio-demographic questionnaires, the Functional Assessment of Cancer Therapy-Ovary (FACT-O), and a global quality-of-life (QOL) item. Reliability was assessed using Cronbach α, and sensitivity using a known group was assessed. Construct validity was tested using exploratory factor analysis.
RESULTS: The sample was primarily white (85.2%), had a mean age of 57.5 years (±12.7 years), and had previously been treated with chemotherapy (75.0%) and/or surgery (93.8%). Approximately 30% of patients reported disturbed sleep, fatigue, or numbness/tingling of at least moderate severity (≥5 on a 0-10 scale). On the ovarian-cancer-specific symptoms, approximately 20% reported back pain, feeling bloated, or constipation of at least moderate severity. Factor analysis revealed six underlying constructs (pain/sleep; cognitive; disease-related and numbness; treatment-related; affective; gastrointestinal-specific). MDASI-OC symptom and interference items had Cronbach α values of 0.90 and 0.89, respectively. The MDASI-OC was sensitive to symptom severity by performance status (p=0.009), QOL (p=0.002), and FACT-O scores (p< 0.001).
CONCLUSIONS: The 27-item MDASI-OC meets common criteria for validation and reliability and is sensitive to expected changes in symptoms related to differences in disease and treatment status.
Volume
130
Issue
2
First Page
323
Last Page
328
ISSN
1095-6859
Published In/Presented At
Sailors, M. H., Bodurka, D. C., Gning, I., Ramondetta, L. M., Williams, L. A., Mendoza, T. R., Agarwal, S., Sun, C. C., & Cleeland, C. S. (2013). Validating the M. D. Anderson Symptom Inventory (MDASI) for use in patients with ovarian cancer. Gynecologic oncology, 130(2), 323–328. https://doi.org/10.1016/j.ygyno.2013.05.009
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
23685012
Department(s)
Department of Pediatrics
Document Type
Article