Transfusion-related acute lung injury (TRALI): current concepts and misconceptions.
Publication/Presentation Date
11-1-2009
Abstract
Transfusion-related acute lung injury (TRALI) is the most common cause of serious morbidity and mortality due to hemotherapy. Although the pathogenesis has been related to the infusion of donor antibodies into the recipient, antibody negative TRALI has been reported. Changes in transfusion practices, especially the use of male-only plasma, have decreased the number of antibody-mediated cases and deaths; however, TRALI still occurs. The neutrophil appears to be the effector cell in TRALI and the pathophysiology is centered on neutrophil-mediated endothelial cell cytotoxicity resulting in capillary leak and ALI. This review will detail the pathophysiology of TRALI including recent pre-clinical data, provide insight into newer areas of research, and critically assess current practices to decrease it prevalence and to make transfusion safer.
Volume
23
Issue
6
First Page
245
Last Page
255
ISSN
1532-1681
Published In/Presented At
Silliman, C. C., Fung, Y. L., Ball, J. B., & Khan, S. Y. (2009). Transfusion-related acute lung injury (TRALI): current concepts and misconceptions. Blood reviews, 23(6), 245–255. https://doi.org/10.1016/j.blre.2009.07.005
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
19699017
Department(s)
Department of Pediatrics
Document Type
Article