Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities.
Publication/Presentation Date
10-3-2025
Abstract
Neonatal encephalopathy (NE) is a significant global health concern. It is a leading cause of long-term neurodevelopmental impairment, with hypoxic-ischaemic perinatal brain injury being the most common underlying contributor. Although therapeutic hypothermia has reduced mortality and improved outcomes for some affected infants, many survivors experience neurodevelopmental disability, including cerebral palsy and/or deficits in cognition, behaviour, and executive functioning. Early and accurate prognostication and identification of injury severity remain a challenge due to evolving clinical signs and multiple etiologies. Magnetic resonance imaging (MRI) is the gold standard for characterizing NE-related brain injury. Diffusion-weighted imaging (DWI) enables early detection of injury, and proton magnetic resonance spectroscopy (
ISSN
1530-0447
Published In/Presented At
Laptook, A., Garvey, A. A., Adams, C., Grant, P. E., Molloy, E. J., Groenendaal, F., Weeke, L. C., Benders, M., Hwang, M., El-Dib, M., Badawi, N., Robertson, N. J., Pang, R., Thayyil, S., Inder, T., Andelius, T. C. K., Kyng, K. J., & Neonatal MRI group; Brain, Development, and Imaging section of the European Society of Pediatric Research (ESPR) (2025). Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities. Pediatric research, 10.1038/s41390-025-04448-5. Advance online publication. https://doi.org/10.1038/s41390-025-04448-5
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
41044228
Department(s)
Department of Pediatrics
Document Type
Article