Determinants of left ventricular mass in children with autosomal recessive polycystic kidney disease.
Publication/Presentation Date
10-7-2025
Abstract
BACKGROUND: Hypertension and left ventricular (LV) hypertrophy (LVH) are common in autosomal recessive polycystic kidney disease (ARPKD). We examined clinical determinants of LV mass in children with ARPKD.
METHODS: Retrospective study of patients with ARPKD with available echocardiogram data. Casual blood pressure (BP) percentiles, 24-h ambulatory BP monitor (ABPM) parameters, antihypertensive medications, and estimated glomerular filtration rate (eGFR) within 6 months of echocardiogram were collected. Outcomes included LV mass Z-score, LV mass index [LVMI in g/m
RESULTS: Thirty patients with ARPKD (median age 7.2 years [IQR 3.4, 12.8]) had echocardiograms, 28 had casual BPs, 11 had ABPMs, and 93% were on antihypertensives. LVH occurred in 23% based on LVMI in g/m
CONCLUSIONS: Young children with ARPKD have a higher burden of hypertension. LV mass was unexpectedly not significantly associated with BP but was negatively associated with eGFR.
ISSN
1724-6059
Published In/Presented At
Lin, M., Rubin, J., Palermo, R. A., Zee, J., & Hartung, E. A. (2025). Determinants of left ventricular mass in children with autosomal recessive polycystic kidney disease. Journal of nephrology, 10.1007/s40620-025-02426-y. Advance online publication. https://doi.org/10.1007/s40620-025-02426-y
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
41053527
Department(s)
Department of Pediatrics
Document Type
Article