Initiation and Duration of Breastfeeding in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study.
Publication/Presentation Date
11-27-2023
Abstract
BACKGROUND AND OBJECTIVES: Breastfeeding has important health benefits for both mother and child. We characterize breastfeeding initiation and duration in mothers with epilepsy relative to control mothers in a large prospective cohort.
METHODS: The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs study is a prospective, multicenter observational, US cohort study. Pregnant individuals with and without epilepsy, aged 14-45 years, were enrolled between December 19, 2012, and February 11, 2016. Exclusion criteria included intelligence quotient (IQ) < 70, and gestational age >20 weeks at enrollment. Breastfeeding was assessed through electronic diary and at study visits until 2 years postpartum. Odds of initiating breastfeeding was compared between cohorts using unadjusted and adjusted logistic regression models. Duration of breastfeeding was compared between cohorts using the log-rank test.
RESULTS: Three hundred fifty-one pregnant individuals with epilepsy and 105 pregnant controls were enrolled. Breastfeeding data were available for 325 mothers with epilepsy and 98 controls. Study cohorts were similar demographically except race (
DISCUSSION: Mothers with epilepsy were less likely to initiate breastfeeding compared with controls; however, this difference was not significant when controlling for maternal IQ and education level. Continuation of breastfeeding once initiated was not different between mothers with and without epilepsy. Seizure control was associated with breastfeeding initiation and duration in mothers with epilepsy.
TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov identifier NCT01730170.
Volume
101
Issue
22
First Page
2266
Last Page
2266
ISSN
1526-632X
Published In/Presented At
Gerard, E. E., Meador, K. J., Robalino, C. P., Brown, C. A., Matthews, A. G., Voinescu, P. E., Kalayjian, L. A., Gedzelman, E., Hanna, J., Cavitt, J., Sam, M., French, J. A., Pack, A. M., Hwang, S. T., Tsai, J. J., Taylor, C., Pennell, P. B., & MONEAD Investigator Study Group (2023). Initiation and Duration of Breastfeeding in the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs Study. Neurology, 101(22), e2266–e2276. https://doi.org/10.1212/WNL.0000000000207812
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
37816636
Department(s)
Department of Pediatrics
Document Type
Article