Three-Year Treatment Outcomes of Ahmed Glaucoma Valve Implantation with Adjunctive Intraoperative and Postoperative Mitomycin C.
Publication/Presentation Date
8-17-2026
Abstract
PURPOSE: To describe 3-year outcomes of Ahmed glaucoma valve (AGV) implantation with adjunctive use of intraoperative and postoperative mitomycin C (MMC).
DESIGN: Retrospective observational consecutive case series.
PARTICIPANTS: One hundred and twenty-one eyes of 95 patients with medically uncontrolled glaucoma who underwent AGV implantation combined with intraoperative and postoperative subconjunctival MMC injections between 2011 and 2017 at University of California, San Francisco Medical Center.
METHODS: Clinical data were extracted from patients' medical records, including intraocular pressure (IOP), number of glaucoma medications, best corrected visual acuity (BCVA), and surgical complications.
MAIN OUTCOME MEASURES: IOP, treatment failure (defined as IOP > 21 mmHg or reduced < 20% from baseline, IOP ≤ 5 mmHg, reoperation for glaucoma, and loss of light perception vision), number of glaucoma medications, best corrected visual acuity (BCVA), and surgical complications.
RESULTS: IOP (mean±SD) decreased from 23.7±9.5 mmHg preoperatively to 12.7±3.9 mmHg at 3 years (p< 0.001), and the number of glaucoma medications (mean±SD) decreased from 2.9±1.0 to 1.3±0.9 (p< 0.001). The cumulative probability of failure at 3-year was 26% (95% CI, 19-34%). BCVA (log MAR mean±SD) remained stable from preoperative vision (logMAR 0.45±0.68 preoperatively, 0.56±0.77 at 3 years, p=0.16). The complication rate was 12% and the most common early postoperative complications were diplopia and hypotony maculopathy.
CONCLUSIONS: AGV implantation combined with intraoperative and postoperative MMC resulted in a significant reduction in IOP and number of glaucoma medications with a low rate of surgical complications and stable BCVA during 3 years of follow-up.
ISSN
2589-4196
Published In/Presented At
Cao, B., Kline, B., Kao, B., Yu, Y., Ying, G. S., Oatts, J. T., Gedde, S. J., Ahmed, I. I. K., & Han, Y. (2026). Three-Year Treatment Outcomes of Ahmed Glaucoma Valve Implantation with Adjunctive Intraoperative and Postoperative Mitomycin C. Ophthalmology. Glaucoma, S2589-4196(26)00134-1. Advance online publication. https://doi.org/10.1016/j.ogla.2026.08.001
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
42607928
Department(s)
Department of Pediatrics
Document Type
Article