Hypofractionated re-irradiation to the brainstem in children with recurrent brain tumors.

Authors

• Timothy V Waxweiler
• Arya Amini
• Yevgeniy Vinogradskiy
• Norman Yeh
• Nicholas K Foreman
• Todd C Hankinson
• Arthur K Liu

Publication/Presentation Date

5-1-2017

Abstract

To characterize radiation necrosis following hypofractionated brainstem re-irradiation in pediatric patients, we reviewed 23 cases with 28 tumors invading or abutting brainstem and treated with hypofractionated re-irradiation from 2004 to 2014. Re-irradiation delivered total doses of 16-30 Gy in two to five fractions. The most commons regimens used were 24 Gy in three fractions and 25 Gy in five fractions. At median follow-up of 12.8 months, median overall survival was 14.7 months and eight in-field recurrences were detected (median time 10.5 months). Five patients experienced symptomatic brainstem necrosis, and all having received 24 Gy in three fractions. Hypofractionated brainstem re-irradiation may be safer in five fractions.

Volume

64

Issue

5

ISSN

1545-5017

Published In/Presented At

Waxweiler, T. V., Amini, A., Vinogradskiy, Y., Yeh, N., Foreman, N. K., Hankinson, T. C., & Liu, A. K. (2017). Hypofractionated re-irradiation to the brainstem in children with recurrent brain tumors. Pediatric blood & cancer, 64(5), 10.1002/pbc.26341. https://doi.org/10.1002/pbc.26341

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

28342300

Department(s)

Administration and Leadership

Document Type

Article