Functional-guided radiotherapy using knowledge-based planning.
Publication/Presentation Date
12-1-2018
Abstract
BACKGROUND AND PURPOSE: There are two significant challenges when implementing functional-guided radiotherapy using 4DCT-ventilation imaging: (1) lack of knowledge of realistic patient specific dosimetric goals for functional lung and (2) ensuring consistent plan quality across multiple planners. Knowledge-based planning (KBP) is positioned to address both concerns.
MATERIAL AND METHODS: A KBP model was created from 30 previously planned functional-guided lung patients. Standard organs at risk (OAR) in lung radiotherapy and a ventilation contour delineating areas of high ventilation were included. Model validation compared dose-metrics to standard OARs and functional dose-metrics from 20 independent cases that were planned with and without KBP.
RESULTS: A significant improvement was observed for KBP optimized plans in V20Gy and mean dose to functional lung (p = 0.005 and 0.001, respectively), V20Gy and mean dose to total lung minus GTV (p = 0.002 and 0.01, respectively), and mean doses to esophagus (p = 0.005).
CONCLUSION: The current work developed a KBP model for functional-guided radiotherapy. Modest, but statistically significant, improvements were observed in functional lung and total lung doses.
Volume
129
Issue
3
First Page
494
Last Page
498
ISSN
1879-0887
Published In/Presented At
Miften, M., Vinogradskiy, Y., Moiseenko, V., Grimm, J., Yorke, E., Jackson, A., Tomé, W. A., Ten Haken, R. K., Ohri, N., Méndez Romero, A., Goodman, K. A., Marks, L. B., Kavanagh, B., & Dawson, L. A. (2021). Radiation Dose-Volume Effects for Liver SBRT. International journal of radiation oncology, biology, physics, 110(1), 196–205. https://doi.org/10.1016/j.ijrobp.2017.12.290
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
29628292
Department(s)
Administration and Leadership
Document Type
Article