Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates.
Publication/Presentation Date
1-1-2020
Abstract
OBJECTIVES: To evaluate the use of sedatives and analgesics during therapeutic hypothermia in encephalopathic neonates and assess associations between medication exposure and hospital outcomes.
STUDY DESIGN: We identified neonates ≥35 weeks gestational age treated with therapeutic hypothermia at 125 neonatal intensive care units between 2007 and 2015. We compared characteristics and hospital outcomes between unexposed neonates and neonates exposed to opioids and/or benzodiazepines.
RESULTS: Opioids were administered to 1 677/2 621 (64%) neonates, and exposure increased from 38% in 2008 to 68% in 2015. Sedation/analgesia varied widely between centers. Opioid-exposed neonates experienced greater durations of respiratory support and were more likely to receive inotropes and inhaled nitric oxide. Mortality during postnatal days 0-3 was lower among opioid-exposed neonates (31/625 [5%]) than unexposed neonates (64/714 [9%]).
CONCLUSIONS: Sedation/analgesia during therapeutic hypothermia is prevalent but not uniform across centers. Prospective studies are needed to assess if exposure independently predicts intensity and duration of physiologic support.
Volume
40
Issue
1
First Page
79
Last Page
88
ISSN
1476-5543
Published In/Presented At
Berube, M. W., Lemmon, M. E., Pizoli, C. E., Bidegain, M., Tolia, V. N., Cotten, C. M., & Greenberg, R. G. (2020). Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates. Journal of perinatology : official journal of the California Perinatal Association, 40(1), 79–88. https://doi.org/10.1038/s41372-019-0533-4
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
31616049
Department(s)
Department of Pediatrics
Document Type
Article