Quantification of Neuromotor Control in

Authors

• Julie M Orlando
• Bintou Bane
• Torrey Chisari
• Jan H Magielski
• Samuel R Pierce
• Kristin Girardi Cunningham
• Charlene Woo
• Sarah Tefft
• Joeylynn Nolan
• Sarah Mckeown Ruggiero
• Michael J Boland
• Jillian L McKee
• Ingo Helbig
• Laura A Prosser

Publication/Presentation Date

12-1-2026

Abstract

BACKGROUND AND OBJECTIVES:

METHODS: In this study, an exploratory analysis to quantify the clinical features of motor control impairment, including tremor, in 23 individuals with

RESULTS: Individuals with

DISCUSSION: Our study provides an understanding of motor control in a rare neurodevelopmental disorder and establishes a paradigm to quantify neuromotor control in individuals with developmental differences. Our observations demonstrate significant relations between motor control measures and developmental function, and a tremor prevalence that exceeds twofold what has been reported in historical, retrospective data sets.

Volume

12

Issue

6

First Page

200439

Last Page

200439

ISSN

2376-7839

Published In/Presented At

Orlando, J. M., Bane, B., Chisari, T., Magielski, J. H., Pierce, S. R., Cunningham, K. G., Woo, C., Tefft, S., Nolan, J., Ruggiero, S. M., Boland, M. J., McKee, J. L., Helbig, I., & Prosser, L. A. (2026). Quantification of Neuromotor Control in STXBP1-Related Disorders With Wearable Sensors. Neurology. Genetics, 12(6), e200439. https://doi.org/10.1212/NXG.0000000000200439

Disciplines

Medicine and Health Sciences | Pediatrics

PubMedID

42921248

Department(s)

Department of Pediatrics

Document Type

Article