Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?
Publication/Presentation Date
10-8-2009
Abstract
Xanthomatous skin lesions and arthritis in children are not a common association. We present the case of a 3 year old girl who presented with xanthomatous lesions in the periungual region of both hands, around the nares and on her forehead, associated with significant arthritis that was clinically compatible with multicentric reticulohistiocytosis. However, pathology of the xanthomatous lesions was more suggestive of papular xanthoma, a disease that is not associated with arthritis. Based on her presentation and the negative lipid workup, she was treated for presumed multicentric reticulohistiocytosis. Multiple treatment strategies were utilized, with improvement on a combination of infliximab, methotrexate, and prednisone. We review the different diagnoses that should be considered in children with xanthomas and arthritis as well as the different pharmacologic therapies used in children with multicentric reticulohistiocytosis.
Volume
7
First Page
15
Last Page
15
ISSN
1546-0096
Published In/Presented At
Matiz, C., Ferguson, P. J., Zaenglein, A., Groh, B., & Bingham, C. A. (2009). Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?. Pediatric rheumatology online journal, 7, 15. https://doi.org/10.1186/1546-0096-7-15
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
19814780
Department(s)
Department of Pediatrics
Document Type
Article