Pediatric superior vena cava syndrome: An evidence-based systematic review of the literature.
Publication/Presentation Date
9-1-2018
Abstract
Superior vena cava syndrome (SVCS) results in vascular, respiratory, and neurologic compromise. A systematic search was conducted to determine the prevalence of pediatric SVCS subtypes and identify clinical characteristics/treatment strategies that may influence overall outcomes. Data from 101 case reports/case series (142 patients) were analyzed. Morbidity (30%), mortality (18%), and acute complications (55%) were assessed as outcomes. Thrombosis was present in 36%, with multi-modal anticoagulation showing improved outcome by >50% (P = 0.004). Infant age (P = 0.04), lack of collaterals (P = 0.007), acute complications (P = 0.005), and clinical presentation may have prognostic utility that could influence clinical decisions and surveillance practices in pediatric SVCS.
Volume
65
Issue
9
First Page
27225
Last Page
27225
ISSN
1545-5017
Published In/Presented At
Nossair, F., Schoettler, P., Starr, J., Chan, A. K. C., Kirov, I., Paes, B., & Mahajerin, A. (2018). Pediatric superior vena cava syndrome: An evidence-based systematic review of the literature. Pediatric blood & cancer, 65(9), e27225. https://doi.org/10.1002/pbc.27225
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
29781569
Department(s)
Department of Pediatrics
Document Type
Article