Phylogenomics of nontuberculous mycobacteria respiratory infections in people with cystic fibrosis.
Publication/Presentation Date
2-10-2023
Abstract
Nontuberculous mycobacteria (NTM) can cause severe pulmonary disease in people with cystic fibrosis (pwCF). These infections present unique challenges for diagnosis and treatment, prompting a recent interest in understanding NTM transmission and pathogenesis during chronic infection. Major gaps remain in our knowledge regarding basic pathogenesis, immune evasion strategies, population dynamics, recombination potential, and the evolutionary implications of host and antibiotic pressures of long-term NTM infections in pwCF. Phylogenomic techniques have emerged as an important tool for tracking global patterns of transmission and are beginning to be used to ask fundamental biological questions about adaptation to the host during pathogenesis. In this review, we discuss the burden of NTM lung disease (NTM-LD), highlight the use of phylogenomics in NTM research, and address the clinical implications associated with these studies.
ISSN
1526-0550
Published In/Presented At
Bolden, N., Mell, J. C., Logan, J. B., & Planet, P. J. (2023). Phylogenomics of nontuberculous mycobacteria respiratory infections in people with cystic fibrosis. Paediatric respiratory reviews, S1526-0542(23)00004-0. Advance online publication. https://doi.org/10.1016/j.prrv.2023.02.001
Disciplines
Medicine and Health Sciences | Pediatrics
PubMedID
36828670
Department(s)
Department of Pediatrics
Document Type
Article